ANALYSIS OF PRE-ANALYTICAL FACTORS AFFECTING THE ACCURACY OF SEROLOGICAL TESTS IN DIAGNOSTICS OF HEPATITIS B AND C

Abstract

Serological diagnostic methods for viral hepatitis B and C play a key role in the early detection, monitoring and control of infections that pose a significant threat to public health. In conditions of the widespread occurrence of these diseases and the high probability of chronization of the infectious process, it is extremely important to ensure high accuracy and reproducibility of laboratory results. The preanalytical stage has a significant impact on the reliability of serological studies, including the correct organization of blood collection, the choice of the type of tubes, compliance with transportation conditions, temperature storage conditions, as well as time intervals between sampling and analysis. Errors at this stage can lead to false negative or false positive results, which will lead to incorrect clinical tactics, delayed initiation of treatment, and potential risks to others..

The purpose of this study is a comprehensive analysis of preanalytical factors that can affect the reliability of serological tests in the diagnosis of hepatitis B and C. The work included an assessment of common disorders at the preanalytical stage and their impact on the final diagnostic results. The data obtained confirm the need to develop and implement clearly regulated standard operating procedures aimed at minimizing errors up to the analytical stage. This will not only improve the accuracy of diagnosis, but also improve the overall quality of laboratory diagnostic care for patients