Molecular Hallmarks of Aging: Integrated Profiling Reveals Epigenetic Erosion and Proteostatic Collapse

Authors

  • David Aphkhazava PhD, Full Professor of Biochemistry at Alte university, Tbilisi, Georgia; Invited Lecturer (Professor) of Biochemistry, University of Georgia, Tbilisi Georgia, Full professor of Biochemistry Georgian National University SEU, Tbilisi Georgia , Invited Lecturer (Professor) of Biophysics and Microbiology, Georgian Technical University, Tbilisi Georgia. Orcid: https://orcid.org/0000-0001-6216-6477
  • Archil Chirakadze PhD, Georgian Techical University, Ivane Javakhishvili Tbilisi State University
  • Nodar Sulashvili MD, PhD, Doctor of Pharmaceutical and Pharmacological Sciences In Medicine, Invited Lecturer (Professor) of Scientific Research-Skills Center at Tbilisi State Medical University; Professor of Medical and Clinical Pharmacology of International School of Medicine at Alte University; Professor of Pharmacology of Faculty of Medicine at Georgian National University SEU, Associate Affiliated Professor of Medical Pharmacology of Faculty of Medicine at Sulkhan-Saba Orbeliani University; Associate Professor of Medical Pharmacology at School of Medicine at David Aghmashenebeli University of Georgia; Associate Professor of Biochemistry and Pharmacology Direction of School of Health Sciences at the University of Georgia. Associate Professor of Pharmacology of Faculty of Dentistry and Pharmacy at Tbilisi Humanitarian Teaching University; Tbilisi, Georgia; Orcid: https://orcid.org/0000-0002-9005-8577.
  • Lolita Shengelia PhD, Invited lecturer of Georgian National University, Tbilisi, Georgia; Invited lecturer of Georgian American University, Tbilisi, Georgia
  • Devanshu Ganje Alte university, Tbilisi, Georgia
  • Rimsha Fatima Rafeeq University of Georgia, Tbilisi, Georgia
  • Ramashish Subhashchandra Vishwakarma University of Georgia, Tbilisi, Georgia
  • Anuja Dhananjay Naikwade Alte University, Tbilisi, Georgia
  • Nithesh Swamy Paramkusham Alte University, Tbilisi, Georgia
  • Mohammed Aniq Zathik University of Georgia, Tbilisi, Georgia
  • Harshita Vimal Sharma Alte University, Tbilisi, Georgia
  • Ayshath Shaharban Cheriya Veettil University of Georgia, Tbilisi, Georgia
  • Jayrajsinh Rathod Alte University, Tbilisi, Georgia
  • Deva Harsha Uday Gundluru University of Georgia, Tbilisi, Georgia
  • Dua Rasool University of Georgia, Tbilisi, Georgia

Keywords:

Aging, DNA Methylation, Epigenetic Drift, Histone Acetylation, Ubiquitin-Proteasome System, Proteostasis, Post-Translational Modifications, Biomarkers, Cellular Senescence, Molecular Hallmarks of Aging

Abstract

Aging is a multifaceted biological process shaped by genetic, epigenetic, and environmental influences. Recent advances in high-throughput technologies have enabled unprecedented exploration of posttranslational modifications (PTMs) and epigenetic remodeling, both of which are central regulators of cellular function during aging. Mass spectrometry-based proteomics, single-cell multi-omics, and spatial epigenetic profiling now allow investigators to track molecular changes at a resolution previously unattainable. Simultaneously, bioinformatics and machine learning approaches facilitate integration of these molecular datasets with clinical phenotypes, revealing predictive biomarkers of age-related disease and therapeutic response. This article synthesizes recent progress in the study of PTMs and epigenetics in aging, highlights novel technological platforms, and discusses the role of computational biology in translating molecular insights into precision medicine for aging populations

Published

2025-09-15

How to Cite

David Aphkhazava, Archil Chirakadze, Nodar Sulashvili, Lolita Shengelia, Devanshu Ganje, Rimsha Fatima Rafeeq, Ramashish Subhashchandra Vishwakarma, Anuja Dhananjay Naikwade, Nithesh Swamy Paramkusham, Mohammed Aniq Zathik, Harshita Vimal Sharma, Ayshath Shaharban Cheriya Veettil, Jayrajsinh Rathod, Deva Harsha Uday Gundluru, & Dua Rasool. (2025). Molecular Hallmarks of Aging: Integrated Profiling Reveals Epigenetic Erosion and Proteostatic Collapse. Modern Scientific Technology, (11). Retrieved from https://ojs.publisher.agency/index.php/MSC/article/view/6772

Issue

No. 11 (2025): Modern Scientific Technology

Section

Biological Sciences

License

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