Research Reviews

Epigenetic Regulation of Longevity-Associated Genes and Clinical Correlates in Aging: Insights from Cancer History and Hematologic Parameters

David Aphkhazava — 2025-08-11

DNA methylation of key tumor suppressor and longevity genes, including TP53, SIRT1, and FOXO3A, changes with age and may reflect cancer history and hematologic status. Using publicly available methylation datasets from whole blood, we analyzed promoter methylation patterns in individuals aged 65–74, 75–84, and 85+, stratified by cancer history, complete blood count (CBC) profile, and red cell distribution width (RDW). Distinct, age-specific trends emerged: in younger elderly groups, TP53 and SIRT1 methylation differed significantly between cancer and non-cancer cases, while FOXO3A methylation correlated with elevated RDW. In the oldest group, higher SIRT1 methylation was seen in cancer-free individuals with normal CBC results, with TP53 and FOXO3A showing smaller variations. These findings highlight the potential of targeted methylation profiling as a minimally invasive biomarker approach for assessing biological aging and disease vulnerability in older populations

PHYTOREMEDIATION OF ORGANIC POLLUTANTS WITH ENDOPHYTIC BACTERIA

Satu Albina Samatkyzy — 2025-08-11

Phytoremediation, the use of plants to remediate contaminated environments, has gained significant attention as an eco-friendly and cost-effective approach to address soil and water pollution. Recent research has highlighted the role of endophytic bacteria—microorganisms that inhabit plant tissues without causing harm—in enhancing the phytoremediation potential of various plant species. This paper explores the mechanisms through which endophytic bacteria contribute to the degradation of organic pollutants, the synergistic interactions between plants and their endophytic partners, and the implications for future remediation strategies. The findings suggest that integrating endophytic bacteria into phytoremediation practices can significantly improve the efficiency of pollutant removal, thereby offering a sustainable solution to environmental contamination.

FEATURES RELEASE OF MINORS FROM CRIMINAL RESPONSIBILITY AND PUNISHMENT

Orsayeva Raissa Anuarovna — 2025-08-11

The article discusses the features of the release of minors from criminal liability and punishment under the legislation of the Republic of Kazakhstan. The also disclosed the content of the legality requirement for such a decision, a detailed analysis of the elements of this content.

LEGAL REGULATION OF PERSONAL NON-PROPERTY RELATIONS UNDER THE LEGISLATION OF THE REPUBLIC OF KAZAKHSTAN

Yu Kai — 2025-08-11

The article examines the legal regulation of personal non-property relations in Kazakhstan, including intangible benefits such as dignity, honor, reputation, privacy, and personal data protection. It analyzes the strengths and weaknesses of current legislation using comparative legal, systematic, formal legal, and analytical methods.

The research focuses on gaps in the regulatory framework, inconsistencies in judicial practice, and the effects of digitalization on individual rights, drawing on national and international legal norms, court decisions, academic literature, and statistical data. A SWOT analysis reveals both the potential for legislative reform and the risks associated with digital threats and the legal illiteracy of the population.. In conclusion, the need for codifying individual rights, developing a judicial methodology for assessing moral harm, and bringing national legislation in line with international human rights standards has been substantiated

AZERBAIJAN TURKEY STRATEGIC COOPERATION AND ITS GEOPOLITICAL EFFECT

G.M.Quliyeva — 2025-08-11

The strategic partnership between Azerbaijan and Turkey has recently generated significant geopolitical effects both bilaterally and regionally. This cooperation is rooted in historical-cultural ties, joint energy and transportation projects, military-political alliances, and mutual support in humanitarian fields. The article analyzes the stages of cooperation development, joint projects in energy and transportation, strategic military alliance, geopolitical shifts in the region, and humanitarian aspects. Ultimately, the importance of the Azerbaijan–Turkey tandem in the South Caucasus, the Turkic world, and global energy security is emphasized.

ОРТА МЕКТЕПТЕ ЭЛЕКТР ЖӘНЕ МАГНЕТИЗМ БӨЛІМІН ОҚЫТУДА ЗАМАНАУИ ТЕХНОЛОГИЯЛАРДЫ ҚОЛДАНУ ӘДІСТЕМЕСІ

Бекенов Жандос Төлебайұлы — 2025-08-11

Мақалада орта мектеп физика курсындағы «Электр және магнетизм» бөлімін оқытуда заманауи технологияларды тиімді қолдану жолдары қарастырылады. Зерттеу барысында интерактивті тақта, виртуалды зертханалар, симуляциялар (PhET, Crocodile Physics), сандық платформалар (Google Classroom, Kahoot, Quizizz), сондай-ақ STEM және STEAM элементтері сияқты заманауи білім беру құралдарының мүмкіндіктері талданды. Сонымен қатар оқушылардың пәнге қызығушылығын арттыру, теориялық білімді тәжірибе арқылы меңгеру, және шығармашылық ойлау қабілеттерін дамытуға бағытталған педагогикалық тәсілдер ұсынылады. Жұмыс жаңартылған білім мазмұны мен критериалды бағалау жүйесі талаптарына сәйкес келеді

ОРТА МЕКТЕПТЕ ФИЗИКАНЫ ОҚЫТУДА ОЙЫН ТЕХНОЛОГИЯЛАРЫН ҚОЛДАНУДЫҢ ӘДІСТЕМЕЛІК НЕГІЗДЕРІ

Нұрланова Әйгерім Талғатқызы — 2025-08-11

Мақалада физика пәнін оқыту үдерісіне ойын технологияларын енгізудің тиімділігі сипатталады. Қазіргі білім беру жүйесінде оқушылардың пәнге деген қызығушылығын арттыру, олардың белсенділігін күшейту және білім сапасын жоғарылату басты міндеттердің бірі болып табылады. Осы мақсатта сабақ барысында ойын элементтерін қолдану арқылы оқушылардың танымдық белсенділігі мен оқу мотивациясы артады. Ойын технологиялары оқытудың дәстүрлі формаларын түрлендіріп, оқушыларды оқу процесіне белсенді түрде қатыстыруға мүмкіндік береді. Физиканың абстрактілі ұғымдарын түсіндіру барысында қолданылатын ойын тәсілдері – ұпай жинау, деңгейлік тапсырмалар, жарыс элементтері, онлайн викториналар – оқушының логикалық ойлауын, топпен жұмыс істеу дағдыларын және пәнге деген қызығушылығын дамытады. Сабақ құрылымында әр кезеңге сәйкес ойын элементтерін енгізу арқылы материалды меңгеру сапасы жақсарады. Эксперименттік зерттеу Алматы қаласындағы мамандандырылған білім беру ұйымында 8-сынып оқушылары арасында жүргізілді. Зерттеуге қатысқан топтарда ойын технологиялары қолданылған жағдайда оқушылардың оқу жетістігі мен белсенділігі жоғары нәтиже көрсетті. Статистикалық өңдеу нәтижесінде әдістің тиімділігін дәлелдеді

РЕЛИГИОЗНОЕ ОБРАЗОВАНИЕ: ИСТОРИЯ, ТРАДИЦИИ И СОВРЕМЕННОСТЬ

Светлана Мамед гызы Адыгезалова — 2025-08-11

Религиозное образование представляет собой сложное явление, охватывающее духовную, нравственную, культурную и правовую сферы жизни общества. Его значение трудно переоценить в условиях глобализации, роста межконфессиональных контактов и вызовов религиозного радикализма. Исторически религиозное образование выполняло функции сохранения и трансляции сакрального знания, морального воспитания и социального регулирования.

Статья освещает эволюцию религиозного образования, его формы в традиционных и современных обществах, а также роль религии в формировании общественного сознания, правового поля и межкультурного диалога, особенно в контексте постсоветского пространства и Азербайджана.

Struktural Dilçilik: Sinxron və Diaxron Yanaşmaların İnkişafı və Əhəmiyyəti

Həsənova Vüsalə Fərrux qızı — 2025-08-11

Bu məqalədə struktural dilçiliyin meydana çıxması və onun həm sinxron, həm də diaxron dilçilikdəki əhəmiyyəti təhlil edilir. Ferdinand de Saussure-un dilin sistem kimi qəbul edilməsi konsepsiyası, fonemlərin struktur və funksional təbiətinin yenidən qiymətləndirilməsinə səbəb olmuş, bununla da fonetikadan fonologiyaya keçid baş vermişdir. Roman Jakobson, Nikolay Trubetzkoy və digər dilçilərin fonemlərin ayırdedici xüsusiyyətlər sisteminə əsaslanaraq tədqiqi, dil dəyişikliklərinin sistemli və qarşılıqlı əlaqəli proses kimi öyrənilməsinə yol açmışdır.

THE INFLUENCE OF LINGUISTIC THEORY ON ENGLISH LANGUAGE TEACHING: A CRITICAL PERSPECTIVE

Dinar Mammadova — 2025-08-11

Linguistics, understood as the scientific exploration of language, has grown into a foundational discipline for modern language education. As English maintains its status as a global lingua franca, educators increasingly rely on linguistic theory to enhance teaching methodologies and design effective curricula. Rather than remaining an abstract academic field, linguistics has offered concrete tools that shape practical classroom strategies. This paper critically explores the diverse ways in which linguistic theories and subfields inform and influence English Language Teaching (ELT), offering both conceptual frameworks and applied teaching solutions.

THE ROLE OF CRITICAL READING IN ENHANCING LINGUISTIC AWARENESS AND ANALYTICAL THINKING IN EFL CONTEXTS

Aliyeva Vafa Samed — 2025-08-11

This article explores the pivotal role of critical reading in the academic development of university students, especially within the framework of foreign language learning. It highlights how critical reading involves both cognitive and metacognitive strategies: while cognitive strategies involve understanding, analyzing, and interpreting texts, metacognitive strategies help learners monitor and regulate their own reading processes through planning, questioning, and visualizing. The article also examines the linguistic, cultural, and structural challenges that students face when engaging with complex academic texts. Practical solutions are proposed, including the enrichment of academic vocabulary, polishing grammar and the implementation of exercises aimed at fostering critical thinking in both L1 and L2.

Innovations in digital systems for modern mining excavators

Nursagat Nurgul Nursagatkyzy — 2025-08-11

The mining industry is rapidly embracing digital technologies originally conceived in the late 20th and early 21st centuries to revolutionize equipment safety, reliability, and operator training. This paper reviews the latest on‑board diagnostic platforms, continuous vibration monitoring, centralized lubrication controls, geolocation systems, and advanced operator simulators that have transformed excavator operations. Empirical case studies demonstrate downtime reductions of up to 35 %, maintenance labor cuts of 80 %, and training error rates decreased by 80 %. We also examine software tools for excavator‑truck fleet sizing and structural life estimation, highlighting how these innovations optimize total cost of ownership (TCO) and extend machine life. Key implementation challenges—including network infrastructure, cybersecurity, and regulatory compliance—are discussed, and best practices for scalable deployment are provided

Assessment of financial results of mergers and acquisitions: analysis on the example of a deal between China and Kazakhstan

Cui Yingying — 2025-08-11

Cross-border mergers and acquisitions (M&As) are a crucial tool for implementing international economic strategies, particularly within the framework of the "One Belt, One Road" initiative. This study aims to comprehensively assess the financial outcomes of such transactions, using the strategic partnership between China and Kazakhstan in the oil and gas industry as an example. The relevance of this work stems from the need to analyze the actual consequences of significant foreign investments on the national economy and participating companies. Instead of testing general hypotheses, this article employs a case study methodology to deeply analyze a specific M&A transaction. We examine both the short-term market reaction to the announcement of the deal and the long-term changes in the operating and financial performance of the Kazakh company following the entry of the Chinese investor. The results of the analysis suggest that, despite a subdued or neutral response from the buyer's stock market in the short term, long-term financial outcomes for the acquired company could be significantly improved through the influx of investment, introduction of new technologies, and optimization of production processes. The study demonstrates that success in cross-border mergers and acquisitions depends less on speculative market expectations and more on the investor's long-term strategic commitment.

Managing Competitiveness in a Globalized Economy: Comparative Lessons from Asia, Central Asia, and the CIS

Jiang Wenhan — 2025-08-11

In the ever-evolving global economy, marked by technological advancements, geopolitical tensions, and supply chain reconfigurations, the challenge of maintaining national and corporate competitiveness has become paramount. Traditional approaches, centered around resource or cost advantages, are proving to be insufficient. This research aims to compare and contrast the strategies employed by two distinct economic models: the innovation and export-driven model of developed Asian nations (illustrated by South Korea and Singapore) and the resource-based model of CIS countries (represented by Russia and Kazakhstan). Employing a comparative analysis framework, this study examines the key determinants of competitiveness, including the quality of human capital, innovation activity, economic diversification, and the institutional environment. The findings of the study indicate that Asian nations are outperforming in terms of competitiveness, thanks to their substantial investments in research and development, the cultivation of human capital, and the fostering of a supportive business environment. Conversely, the economies of the Commonwealth of Independent States (CIS) face obstacles, despite their abundant natural resources, due to their heavy reliance on the export of raw materials and the need for structural reforms. The study concludes that in the 21st century, long-term competitiveness hinges on the capacity of governments and businesses to cultivate a knowledge-based economy rather than a resource-based one

Organizational Business Process Reengineering: Methodological Perspectives

Jiang Yun — 2025-08-11

In the age of global digital competition, the process of reengineering business processes (RBP) is becoming an essential component of the strategy for companies aiming to achieve significant improvements. This article delves into the methodological aspects of RBP in the context of two distinct economic models in Asia: China, a global technological leader, and Kazakhstan, a rapidly developing digital hub in Central Asia. This paper conducts a comparative analysis of RBP approaches, identifies key success factors driven by national strategies (such as China's "Made in China 2025" and Kazakhstan's "Digital Kazakhstan"), and examines the influence of specific socio-cultural and economic conditions on transformational processes. The article incorporates up-to-date statistical data on the digitalization of China's and Kazakhstan's economies, presents two tables summarizing success factors and case study outcomes, and includes a diagram illustrating a universal digital reengineering model. The concluding section delves into the distinctive hazards and practical consequences of implementing RBP approaches in various nations, providing valuable perspectives for global business and academia

From Directive Control to Adaptive Strategy: A Comparative Analysis of Strategic Planning Mechanisms for Effective Governance

Liu Junxian — 2025-08-11

In the face of the ongoing instability of the global economy, organizations need to be able to effectively formulate and implement strategies in order to survive and succeed. Traditional models of long-term planning are giving way to more flexible and adaptive approaches. This paper aims to compare two fundamentally different, but equally successful, strategic planning mechanisms: the cascaded, process-oriented Hoshin Kanri system (using Toyota as an example), and the decentralized, results-oriented model (using Netflix as an example). The paper uses the methodology of case study analysis to explore how these mechanisms link high-level strategies with operational activities, influence staff engagement, and shape organizational culture. The analysis results indicate that the Toyota model, which is based on the principles of continuous improvement and two-way communication, provides the highest level of operational efficiency and quality in a complex manufacturing environment. This model is based on "freedom and responsibility", and provides a strategic context instead of simply cascading tasks. This approach drives innovation and speed at Netflix, a company that operates in a creative and rapidly evolving industry. The study concludes that there is not a single "best" management model. The effectiveness of a particular model depends on its alignment with the industry's context, the organization's culture, and the company's strategic priorities.

Corporate Culture as a Driver of Organizational Performance: Comparative Analysis of Alibaba and Uzum

Zhang Xingang — 2025-08-11

in the era of digital transformation—particularly across the "New Silk Road" corridor—corporate culture has emerged as a decisive factor shaping the pace and scale of success for tech companies. This study explores how organizational culture influences performance by comparing two emblematic firms at different stages of maturity: the global powerhouse Alibaba Group (China) and Central Asia’s first tech unicorn, Uzum (Uzbekistan). Using a comparative case study approach and the Competing Values Framework, the research illustrates how distinct cultural models can drive exceptional outcomes. Alibaba’s success stems from a fusion of mission-driven values and adaptive transformation, while Uzum thrives on a culture of rapid responsiveness and market agility. Supported by comparative data tables, the study argues that cultural effectiveness is directly tied to how well it aligns with market dynamics and strategic goals

Database Integration and Implementation of Algorithmic Models in the R Programming Language

Elza Bitsadze — 2025-08-11

The integration of databases and the implementation of algorithmic models in the R programming language have become essential components in modern data analysis and statistical computing. R, as a versatile open-source environment, provides extensive tools and packages that facilitate efficient data retrieval, processing, and advanced analytical modeling directly from various database systems. This study focuses on bridging the gap between raw data stored in relational and non-relational databases and the analytical capabilities offered by R, enabling seamless workflows for data scientists and statisticians.

The research explores methods to connect R with popular database management systems such as MySQL, PostgreSQL, and MongoDB, utilizing packages like DBI, RMySQL, and mongolite. It emphasizes best practices for data extraction, transformation, and loading (ETL) within R to prepare datasets for modeling. Subsequently, the study delves into the implementation of algorithmic models, including supervised learning techniques such as regression analysis, classification, and ensemble methods, as well as unsupervised learning like clustering. The use of prominent R packages such as caret, randomForest, and e1071 is demonstrated for building, validating, and tuning these models.

Moreover, the paper discusses feature engineering and data pre-processing techniques critical to improving model performance and interpretability. Visualization of data and model results using packages like ggplot2 and interactive dashboards through Shiny are also presented as integral components of the analytical pipeline.

By integrating databases directly with R and implementing sophisticated algorithmic models, organizations can achieve more dynamic, reproducible, and scalable data science workflows. This integration not only enhances decision-making processes by providing real-time insights but also supports reproducible research practices. The study concludes by highlighting challenges such as handling large-scale data, ensuring data security during transfer, and optimizing computational resources within R.

Ultimately, this work underscores the powerful synergy between database technologies and R programming, offering a comprehensive framework for data-driven analytics and decision support in various application domains including finance, healthcare, and business intelligence.

Тарих сабағында қазақ хандарының әлеуметтік-саяси реформаларын оқытуда қолданылатын жаңа әдістері

Б.А. Енсебаева — 2025-08-11

Бұл мақалада тарих сабағында Қазақ хандығы кезеңіндегі хандардың әлеуметтік-саяси реформаларын оқыту барысында қолданылатын заманауи педагогикалық әдістер қарастырылады. Қазақ хандары жүргізген реформалар – ел басқару жүйесін жетілдіру, ру-тайпалар арасындағы бірлікті нығайту, құқықтық тәртіп орнату және әлеуметтік әділеттілікті қамтамасыз етуге бағытталған тарихи маңызды өзгерістер. Мақалада оқушылардың тарихи танымын арттыру мақсатында жаңа тәсілдер: цифрлық технологиялар, тарихи симуляциялар, кейс-стади, уақыт сызығы, инфографика және проблемалық оқыту әдістерінің тиімділігі талданады.

Қазіргі білім беру жүйесінде оқушының сыни ойлауын, тарихи пайымдауын дамыту өзекті мәселе. Осы тұрғыда, Қазақ хандарының реформаларын заманауи әдістер арқылы оқыту – тарихты жаңаша түсінуге жол ашады және тарихи сана қалыптастыруға ықпал етеді.

Тарих сабағында Қазақ хандарының әлеуметтік-саяси реформаларын оқытуда жаңа әдістердің мазмұнын ашу және олардың оқушы жетістігіне әсерін негіздеу.

Жаңа оқыту әдістері оқушылардың танымдық белсенділігін арттырып, тарихи білімдерін өмірмен байланыстыруға мүмкіндік береді.

Impact asymétrique de la crise financière de 2008 selon le niveau de richesse et d'intégration économique des pays

Hasimbola Anita, RAKOTOZAFY — 2025-08-11

Cet article propose une analyse approfondie des crises financières internationales, en retraçant leur évolution historique, identifiant leurs formes typiques et mobilisant les principales théories pour en expliquer les causes et mécanismes. L’attention est centrée sur la crise financière internationale de 2008, considérée comme un choc systémique majeur. L’étude de cas empirique repose sur une base de données regroupant les taux de croissance de 87 pays à revenus élevés et 25 pays à faibles revenus dont Madagascar.

Deux analyses statistiques sont menées : (1) une ANOVA à mesures répétées met en évidence une chute très significative du taux de croissance entre 2007 (avant crise) et 2009 (après crise) dans les deux groupes de pays. C’est l’effet-choc confirmant le caractère fortement déstabilisateur de cette crise financière majeure affectant l’ensemble des économies mondiales. Et, (2) une analyse statistique complémentaire pour évaluer le temps de reprise entre 2007 (avant) et mi-2013 (après), pour valider le propos de Reinhart & Rogoff (2014). Nous avons vu que 7 ans après la crise de 2008, seuls les pays pauvres semblent avoir retrouvé leur niveau de croissance d’avant-crise, car les pays riches – aux économies très interconnectées – continuent de subir une baisse significative de leur croissance ; ce qui infirme leur théorie.

Ces résultats valident l’hypothèse d’un impact asymétrique de la crise de 2008 selon le niveau de richesse et d’interconnexion économique des pays. L’article conclut par les leçons prises en réponses à la crise, entre autres, l’indépendance de la politique monétaire, le déploiement des outils non conventionnels, la réforme structurelle du secteur bancaire ; que sont des mesures prises par les grandes Banques centrales nationales comme la Fed, la BCE... En outre, les organismes internationaux, les régulateurs supranationaux et les gouvernements nationaux ont promu et mis en œuvre les réformes réglementaires, macroprudentielles, de transparence et de coopération