RETINOBLASTOMA: A MODERN VIEW OF THE PROBLEM

Authors

  • Arman Khozhayev Professor of the S.N. Nugmanov Department of Oncology, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • Aidana Bekturova Resident ophthalmologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • Gulzhan Matkarim Resident ophthalmologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • Gulzhan Matkarim Resident ophthalmologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • Ayagoz Yessenova Resident ophthalmologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • Aksaule Musabek Resident ophthalmologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • Aidana Omirzak Resident ophthalmologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • Kuralay Ryskali Resident ophthalmologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • Bakhytzhan Makhsotov Resident ophthalmologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • Nazerke Amanbekova Resident ophthalmologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • Kaisar Asaukhan Resident ophthalmologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan
  • Aiganym Abseterova Resident ophthalmologist, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan

Keywords:

oncology, ophthalmology, retinoblastoma, incidence, etiopathogenesis, classification systems, screening, visual acuity, biomarkers, RB1 gene, DNA, genome sequencing, diagnostics, treatment, quality of life, prognosis

Abstract

This scientific and analytical work presents modern clinical and diagnostic data concerning the most common malignant intraocular tumor in children – retinoblastoma. The issues of etiopathogenesis, genetic and molecular features of this pathology, assessment of the role of biomarkers in diagnostics and prognosis of the disease are covered in detail. Promising directions for the development of new and improved diagnostic and therapeutic approaches, genetic causes of this pathology, possibilities of whole genome sequencing for studying the mutation landscape, currently used classification systems of retinoblastoma, available possibilities of clinical screening are described. The publication shows that studies of the molecular basis of the disease also led to deciphering subsequent events and, thus, to the discovery of biomarkers and associated targeted therapies. In addition, improvements in molecular biology methods contributed to the development of effective methods of early diagnostics, genetic counseling and disease prevention. The issues of visual acuity assessment and improving the quality of life of patients are also comprehensively considered

Published

2025-06-09

How to Cite

Arman Khozhayev, Aidana Bekturova, Gulzhan Matkarim, Gulzhan Matkarim, Ayagoz Yessenova, Aksaule Musabek, Aidana Omirzak, Kuralay Ryskali, Bakhytzhan Makhsotov, Nazerke Amanbekova, Kaisar Asaukhan, & Aiganym Abseterova. (2025). RETINOBLASTOMA: A MODERN VIEW OF THE PROBLEM. Scientific Results, (10). Retrieved from https://ojs.publisher.agency/index.php/SR/article/view/6436

Issue

No. 10 (2025): Scientific Results

Section

Medical Sciences

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.