Features of preclinical studies of local anesthetic activity of new compounds

Khaiitova Malika; Satbayeva Elmira; Gasanov Eskendir; Malkova Tamara

Authors

Khaiitova Malika 3rd year doctoral student of the "Medicine" specialty, master of medical sciences, assistant of the Pharmacology Department, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Satbayeva Elmira PhD, associate professor, head of the Pharmacology Department, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Gasanov Eskendir 5th year student of the "General Medicine" specialty, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan
Malkova Tamara assistant of the Pharmacology Department, Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan

Keywords:

preclinical studies, experiment, infiltration anesthesia, conduction anesthesia

Abstract

The search and development of new drugs is one of the leading directions in pharmacology, due to the limited effectiveness of many drugs and the presence of a high risk of side effects. In particular, the study of compounds with local anesthetic activity is still relevant. Local anesthesia is used in many areas of medicine, thereby achieving the necessary level of anesthesia during various manipulations. However, actively used local anesthetics are far from ideal. For this reason, research is continuing to study the local anesthetic activity of various derivatives, where preclinical studies are required to assess their safety and effectiveness before a person receives the created drugs. This paper describes the main experimental models on laboratory animals used for testing compounds in order to identify local anesthetic effects during terminal, infiltration and conduction anesthesia.

Features of preclinical studies of local anesthetic activity of new compounds

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