Global Data Analysis of Aging and Health: Cross-Country Variations, Determinants, and Implications for Healthy Longevity

Authors

  • David Aphkhazava PhD, Full Professor of Biochemistry at Alte university, Tbilisi, Georgia; Invited Lecturer (Professor) of Biochemistry, University of Georgia, Tbilisi Georgia, Full professor of Biochemistry Georgian National University SEU, Tbilisi Georgia , Invited Lecturer (Professor) of Biophysics and Microbiology, Georgian Technical University, Tbilisi, Georgia. Orcid: https://orcid.org/0000-0001-6216-6477
  • Archil Chirakadze PhD, Georgian Techical University, Ivane Javakhishvili Tbilisi State University
  • Levan Gulua PhD, Professor, Head of bachelor program of Biomedicine at University of Georgia, Tbilisi, Georgia
  • Nodar Sulashvili MD, PhD, Doctor of Pharmaceutical and Pharmacological Sciences In Medicine, Invited Lecturer (Professor) of Scientific Research-Skills Center at Tbilisi State Medical University; Professor of Medical and Clinical Pharmacology of International School of Medicine at Alte University; Professor of Pharmacology of Faculty of Medicine at Georgian National University SEU, Associate Affiliated Professor of Medical Pharmacology of Faculty of Medicine at Sulkhan-Saba Orbeliani University; Associate Professor of Medical Pharmacology at School of Medicine at David Aghmashenebeli University of Georgia; Associate Professor of Biochemistry and Pharmacology Direction of School of Health Sciences at the University of Georgia. Associate Professor of Pharmacology of Faculty of Dentistry and Pharmacy at Tbilisi Humanitarian Teaching University; Tbilisi, Georgia; Orcid: https://orcid.org/0000-0002-9005-8577.
  • Tamar Okropiridze Doctor of Medical Sciences, Professor at Alte University, Tbilisi, Georgia
  • Aditya Panchal Alte University, Tbilisi, Georgia
  • Deva Harsha Uday Gundluru University of Georgia, Tbilisi, Georgia
  • Harshita Vimal Sharma Alte University, Tbilisi, Georgia
  • Anuja Dhananjay Naikwade Alte University, Tbilisi, Georgia
  • Krupa Kavale MD, Alte University, Tbilisi, Georgia
  • Devanshu Ganje MD, Alte University, Tbilisi, Georgia

Keywords:

aging, healthy life expectancy, HALE, DALYs, frailty, lifestyle index, socioeconomic determinants, global health inequality, morbidity compression, longevity, chronic disease, epigenetic aging, healthspan, population aging, preventive health policy

Abstract

Population aging represents one of the most profound global demographic transitions of the 21st century, yet the quality of these additional years of life varies significantly between countries. This study integrates comparative data on Health-Adjusted Life Expectancy (HALE), disability-adjusted life years (DALYs), frailty indices, and lifestyle indicators to analyze cross-national differences in aging-related health outcomes. Using synthesized data from the Global Burden of Disease (GBD), WHO databases, and published cohort studies, we identify the socioeconomic, environmental, and behavioral determinants driving disparities in healthy longevity.
Results demonstrate that high-income countries experience pronounced compression of morbidity, maintaining longer periods of health despite aging, while low- and middle-income countries gain years largely burdened by chronic disease and functional decline. Gender and age stratifications reveal systematic inequalities: women outlive men but spend proportionally more years in poor health, and older adults in undeveloped regions face nearly double the disease burden of their counterparts in developed nations. Moreover, a strong positive correlation (r = 0.92, p < 0.001) between the Healthy Lifestyle Index and HALE confirms the critical role of behavioral factors—such as diet, activity, and smoking prevention—in determining healthspan.
This comparative analysis highlights that biological aging is profoundly shaped by socioeconomic and policy contexts. Integrated strategies—combining chronic-disease prevention, equitable healthcare access, and population-wide lifestyle interventions—are essential to ensure that global longevity gains translate into genuinely healthy aging.

Published

2025-10-13

How to Cite

David Aphkhazava, Archil Chirakadze, Levan Gulua, Nodar Sulashvili, Tamar Okropiridze, Aditya Panchal, Deva Harsha Uday Gundluru, Harshita Vimal Sharma, Anuja Dhananjay Naikwade, Krupa Kavale, & Devanshu Ganje. (2025). Global Data Analysis of Aging and Health: Cross-Country Variations, Determinants, and Implications for Healthy Longevity. Academics and Science Reviews Materials, (11). Retrieved from https://ojs.publisher.agency/index.php/ASCRM/article/view/6884

Issue

No. 11 (2025): Academics and Science Reviews Materials

Section

Biological Sciences

License

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