PATHOGENESIS OF HUMAN RHINOVIRUSES (HRVs)

Abstract

Human Rhinovirus compromising of 3 species (A, B, C) are mainly responsible for mild upper respiratory tract infections like common cold, but can cause exacerbation in asthmatic & COPD patients. HRV C has several characteristics similar to HRV A, but uses a distinct receptor for host cell entry (CDHR3). This strain is known to cause over half of the infections in children. Thus, identification of HRV C infection is necessary to target therapeutic interventions to treat the at-risk individuals.