IMMUNOHİSTOCHEMİCAL CHARACTERİSTİCS OF THE ADENOHYPOPHYSİS DURİNG THE COMBİNED EFFECT OF HYPOXİA AND İNFECTİON

Abstract

Severe pathologies develop in the body with the simultaneous occurrence of hypoxia and infections of various origins [1]. Thus, due to inflammation, general intoxication, damage to lymphoid tissues and the microcirculatory network, as well as the accumulation of microbes and activated leukocytes at the site of inflammation, they cause extremely serious disturbances in the regional supply of oxygen (O2) to cells and tissues, and the occurrence of hypoxia [2, 3]. Hypoxia involves a lack of O2 that occurs to meet the needs of inflamed resident cells, invading inflammatory cells, and in some cases, proliferating pathogens [4]. Lack of O2 and disruption of its supply lead to tissue inflammation, susceptibility to ischemia, disease progression, and the occurrence of autoimmunity in the body [5, 6].

On the other hand, chronic inflammation caused by prolonged infection causes a decrease in blood supply to tissues and cells as a result of the combined effect of vascular pathology and microthrombosis [4, 5]. At the same time, an increase in the need for O2, as well as a decrease in the supply of O2 to the body, accelerates the development of hypoxia observed during infection [3].

Information about the combined action of both factors in the literature is very scarce and fragmentary; a detailed study of these factors, their relationships and systematic study is very relevant for modern medicine [6-8].