MODERN CONCEPTS OF THE ETIOLOGY AND PATHOGENESIS OF ATHEROSCLEROSIS OF CENTRAL VESSELS

Abstract

Arterial thrombotic and thromboembolic complications remain one of the most pressing issues in modern cardiology. Mortality from CVD has been a leader in statistics for many years in European countries, as well as in Kazakhstan and neighboring countries. The most important problem in cardiology today, as it was a hundred years ago, is atherosclerosis of the central arteries. To date, this issue has been studied many times and comprehensively, theories of the origin and development of atherosclerosis of the main arteries have been described, risk factors have been identified, and principles of treatment and prevention have been developed. However, any practicing physician periodically encounters a discrepancy when a patient, against the background of a normal lipid profile, develops and rapidly progresses atherosclerotic lesions of arterial vessels, and, conversely, there are no signs of atherosclerosis with constantly high levels of blood lipids. Recently, the main areas of scientific research have been devoted mainly to the study of additional biochemical markers, their role in the pathogenesis of atheromatosis