Epigenetic Regulation of Longevity-Associated Genes and Clinical Correlates in Aging: Insights from Cancer History and Hematologic Parameters

Authors

  • David Aphkhazava Alte university,Tbilisi,Georgia, University of Georgia, Tbilisi Georgia, Georgian National University SEU, Tbilisi Georgia , Georgian Technical University, Tbilisi Georgia
  • Zilan Hamza Hazm Alte university,Tbilisi,Georgia
  • Amir Assad Mir Alte university,Tbilisi,Georgia
  • Dhartiben Patel Alte university,Tbilisi,Georgia
  • Manish Reddy Mogilahalli Ramachandrappa Alte university,Tbilisi,Georgia
  • Merlyn Joseph Stalin Vellalar Alte university,Tbilisi,Georgia
  • Komal Dashrath Khichirao Alte university,Tbilisi,Georgia

Abstract

DNA methylation of key tumor suppressor and longevity genes, including TP53, SIRT1, and FOXO3A, changes with age and may reflect cancer history and hematologic status. Using publicly available methylation datasets from whole blood, we analyzed promoter methylation patterns in individuals aged 65–74, 75–84, and 85+, stratified by cancer history, complete blood count (CBC) profile, and red cell distribution width (RDW). Distinct, age-specific trends emerged: in younger elderly groups, TP53 and SIRT1 methylation differed significantly between cancer and non-cancer cases, while FOXO3A methylation correlated with elevated RDW. In the oldest group, higher SIRT1 methylation was seen in cancer-free individuals with normal CBC results, with TP53 and FOXO3A showing smaller variations. These findings highlight the potential of targeted methylation profiling as a minimally invasive biomarker approach for assessing biological aging and disease vulnerability in older populations

Published

2025-08-11

How to Cite

David Aphkhazava, Zilan Hamza Hazm, Amir Assad Mir, Dhartiben Patel, Manish Reddy Mogilahalli Ramachandrappa, Merlyn Joseph Stalin Vellalar, & Komal Dashrath Khichirao. (2025). Epigenetic Regulation of Longevity-Associated Genes and Clinical Correlates in Aging: Insights from Cancer History and Hematologic Parameters. Research Reviews, (10). Retrieved from https://ojs.publisher.agency/index.php/RR/article/view/6672

Issue

No. 10 (2025): Research Reviews

Section

Biological Sciences

License

Creative Commons License

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